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We have one entry that includes the term major depressive.
major depressive disorder
noun: a serious mood disorder involving one or more episodes of intense psychological depression or loss of interest or pleasure that lasts two or more weeks and is accompanied by irritability, fatigue, poor concentration, sleep disturbances, weight gain or loss, feelings of worthlessness or guilt, and sometimes suicidal tendencies : clinical depression, major depression —abbreviation MDD
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Merriam-Webster unabridged
